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Rare wild goats in Northumberland prove to be a genetically distinct breed
Rare wild goats in Northumberland prove to be a genetically distinct breed Gaby Clark Scientific Editor Robert Egan Associate Editor New research shows Cheviot goats are one of the UK's most genetically distinct goat populations. Led by Newcastle University, this is the first genetic study to determine the ancestry and genetic health of a UK feral goat population. It provides a genetic assessment of the Cheviot goats in Northumberland's College Valley, identifying them as a historically...
Demographic history, geographic distance, and landscape features shape the genetic divergence of wild tigers in northeast India
Habitat fragmentation creates small, isolated populations that are vulnerable to inbreeding, genetic drift, and a high genetic load. For conservation management, it is essential to distinguish contemporary landscape resistance from historical demographic processes as drivers of these genetic patterns, especially for conservation priority regions such as northeast India, which intersects two major tigers conservation landscapes. We studied the genetic structure and landscape connectivity of...
Genetic Architecture of Reproduction and Longevity in Historical Dutch Cohorts
Life-history theory predicts a trade-off between reproduction and survival, often invoked to explain human ageing through antagonistic pleiotropy, yet evidence for a genetic trade-off between fertility and longevity in humans remains mixed. We tested whether reproductive traits and lifespan are linked by additive genetic covariance in a large historical Dutch genealogical dataset comprising individuals born between 1850 and 1915. Using quantitative genetic animal models, we estimated...
Huge study of Alzheimer’s genetics identifies new drug targets
The biggest genetic study of Alzheimer’s disease so far has identified 127 gene locations that are associated with the condition, of which 48 are new. The study also pinpoints several genes that could be prioritised as drug targets and cell types linked to a higher genetic risk of the condition. “It’s an exciting time for Alzheimer’s genetics,” says Rudolph Tanzi at Massachusetts General Hospital, who provided evidence of the first Alzheimer’s-linked gene, APP, in 1987.
A Low-Cost, High-Throughput Design-Build-Test Pipeline for Engineering Genetic Systems: Stress Testing with Complex Structural Proteins
Genetic systems engineering is constrained by high DNA synthesis costs, assembly inefficiencies, and challenges in expressing complex proteins. To address these limitations, we developed a highly parallel, low-cost pipeline for the design, assembly, and functional screening of genetic systems, which we stress-tested on highly repetitive structural proteins, including spider silk, biocements, reflectins, and talins. The integrated pipeline combines computational genetic systems design,...
Local genetic neighbourhoods but resilient gene flow across anthropogenic landscapes in the red campion (Silene dioica)
In the plant kingdom, gene flow occurs through pollen and seed dispersal, shaping both within-population spatial genetic structure and among-population genetic differentiation. Anthropogenic land-use change can affect levels of gene flow by reducing pollinator abundance and altering pollen and seed dispersal pathways. Yet, how environmental features shape gene flow events in common herbaceous plants - a fundamental building block of many ecosystems - remains poorly understood.
Scientists discover inherited traits that break Mendel’s Laws of genetics
Scientists discover inherited traits that break Mendel’s Laws of genetics - Date: - June 1, 2026 - Source: - Johns Hopkins Medicine - Summary: - A major mouse study found that some inherited traits are passed down through epigenetic changes that break the classic rules of genetics. Researchers discovered hundreds of cases where these chemical DNA marks behaved unexpectedly, including some that seemed to emerge out of nowhere. They also identified the first known naturally occurring...
Leap in DNA synthesis slashes time to build new genetic sequences
A new method for writing DNA promises to unlock the potential of generative AI in biology, giving scientists a fast, affordable, and accurate way to physically build the novel genetic sequences that predictive models are now producing faster than anyone can construct them. The technique, called Sidewinder, can assemble dozens of genetic sequences simultaneously in a single test tube, producing just one incorrect junction for every 10 million assembly events—a level of precision that far...
Developing engineering strategies to enhance the genetic stability of fatty alcohol-producing strains for production scale-up
Robust strain stability is essential for industrial-scale fatty alcohol production, as metabolic burden and toxicity not only constrain productivity but also create selective pressure for low-producing or non-producing subpopulations. This genetic instability leads to genetic heterogeneity and compromises strain performance during large-scale fermentation. In this study, we investigated the production stability of fatty alcohol-producing Yarrowia lipolytica strains and developed systematic...
Genetically modified worms can now produce and deliver drugs inside a living body, scientists say
Genetically modified worms can now produce and deliver drugs inside a living body, scientists say In a proof-of-concept lab experiment, scientists demonstrated that intestinal parasites could make and release therapeutic agents inside a living host. Scientists genetically tweaked a tiny, worm-like parasite to produce a life-saving antitoxin from inside a living host. In a first-of-its-kind study, researchers modified the hookworm Ancylostoma ceylanicum so that it produces antibodies that...