Junction 24
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M25 traffic live: Motorway fire causes traffic chaos as 999 crews rush to scene
Motorway fire causes traffic chaos as 999 crews rush to scene Traffic is being held anti-clockwise on the M25 between Junction 25 for Enfield and Junction 24 for Potters Bar due to a vehicle fire with four miles of congestion Motorists face rush-hour chaos on the M25 with traffic held due to a vehicle fire. The anti-clockwise carriageway is affected between Junction 25 for Enfield and Junction 24 for Potters Bar and drivers have been told to expect delays of half-an-hour with four miles of...
Police officer wept as he faced drug-driver who left him with life-changing injuries
Police officer wept as he faced drug-driver who left him with life-changing injuries Shaun Orchard, 23, has been jailed for three years and two months for crashing into a police vehicle and leaving PC Rushton with life-changing injuries in Stockport in April last year A cocaine and alcohol-fuelled driver who crashed into a police vehicle and left an officer with life-changing injuries has been jailed. Shaun Orchard, 23, was sentenced to three years and two months in prison after the...
A Human Vocal Fold Organ-On-Chip for Studying Platform-Dependent Mucosal Responses to Particulate Matter
Coarse particulate matter (PM10) deposits at the vocal fold (VF) mucosa, yet upper airway responses remain poorly characterized. Existing in vitro VF models use monocultures that lack the stratified epithelium, lamina propria, and physiological perfusion. We developed a chip-based co-culture model of human VF mucosa and applied it to acute PM10 exposure.
A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.
Tube strikes live: Full list of London Underground lines affected as walkout begins
Tube strikes live: Full list of London Underground lines affected as walkout begins London Underground tube strikes are underway with no service on the Circle Line, the Piccadilly Line, the Metropolitan line between Baker Street and Aldgate, and the Central line between White City and Liverpool Street Tube strikes are causing travel chaos across London this morning with the capital hit by the closures of two lines, partial closures to two others and major disruption across the rest of the...
Tube strikes 2026 live: London chaos with multiple Tfl lines hit - full list
Tube strikes 2026 live: London chaos with multiple Tfl lines hit - full list There is more travel misery for commuters in London this morning with underground lines either suspended or busier than usual London has been hit by the second major Tube strike in a week this morning, bringing travel misery across the capital and no service at all on two lines and parts of four others. The walkout follows an earlier strike on Tuesday which left crowds of people stranded on platforms while others...