Lipidated ApoE
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Lipidated ApoE is found in nanoscale proximity to Aβ aggregates in human Alzheimer brains.
Apolipoprotein E (APOE) associates with amyloid plaques A{beta} in Alzheimer disease (AD). The {epsilon}4 allele of apolipoprotein E (APOE{epsilon}4) is the strongest genetic risk factor for sporadic AD and exacerbates A{beta} plaque burden relative to APOE{epsilon}3 and APOE{epsilon}2. The majority of ApoE associates with multiple lipid classes to form lipoproteins both in the brain and the periphery.