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Lipidated ApoE is found in nanoscale proximity to Aβ aggregates in human Alzheimer brains.
Apolipoprotein E (APOE) associates with amyloid plaques A{beta} in Alzheimer disease (AD). The {epsilon}4 allele of apolipoprotein E (APOE{epsilon}4) is the strongest genetic risk factor for sporadic AD and exacerbates A{beta} plaque burden relative to APOE{epsilon}3 and APOE{epsilon}2. The majority of ApoE associates with multiple lipid classes to form lipoproteins both in the brain and the periphery.
SC-TauPath: A Structural Connectivity Attribution Framework for Mapping Tau Propagation Pathways in Alzheimer's Disease
arXiv:2606.04066v1 Announce Type: cross Abstract: Understanding how structural connections are associated with tau propagation in Alzheimer's disease (AD) remains a central open question, yet existing computational models either rely heavily on biophysical assumptions or lack neurobiologically interpretable pathway maps. We present SC-TauPath, a structural connectivity (SC) attribution framework that maps tau propagation pathways from in vivo neuroimaging data. SC-TauPath combines a Network...
Brain-Atlas-Guided Generative Counterfactual Attention for Explainable Cognitive Decline Diagnosis Using Multimodal Connectomes
new Abstract: Mild cognitive impairment (MCI) and subjective cognitive decline (SCD) are closely associated with the early Alzheimer's disease continuum, where accurate and explainable diagnosis is important for early risk assessment and intervention. Existing connectome-based deep learning models can improve classification performance but often provide limited insight into disease-related functional and structural connectivity changes. This paper proposes an atlas-knowledge-guided...
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis
Abstract Clonal haematopoiesis (CH) activates inflammation and increases the risk of atherosclerosis1,2. Whether lifestyle alters CH clone expansion or the phenotypic programming of CH mutant cells, thereby affecting atherosclerosis, is unknown. Here, in humans and mice and across mutations in Jak2, Tet2, Trp53 and Dnmt3a, we demonstrate mutation-dependent responses to sleep and exercise in CH and show that mutant cells are uniquely sensitive to lifestyle.
Ultra-processed foods may be stealing your focus even if you eat healthy
Ultra-processed foods may be stealing your focus even if you eat healthy - Date: - June 9, 2026 - Source: - Monash University - Summary: - A study of more than 2,100 adults found that eating more ultra-processed foods was linked to poorer attention and slower mental processing, even among people with otherwise healthy diets. Researchers also found higher consumption was associated with increased dementia risk factors, raising concerns about the hidden cognitive costs of heavily processed...
Huge study of Alzheimer’s genetics identifies new drug targets
The biggest genetic study of Alzheimer’s disease so far has identified 127 gene locations that are associated with the condition, of which 48 are new. The study also pinpoints several genes that could be prioritised as drug targets and cell types linked to a higher genetic risk of the condition. “It’s an exciting time for Alzheimer’s genetics,” says Rudolph Tanzi at Massachusetts General Hospital, who provided evidence of the first Alzheimer’s-linked gene, APP, in 1987.
Living brain gene activity revealed noninvasively through programmable blood test
Living brain gene activity revealed noninvasively through programmable blood test Stephanie Baum Scientific Editor Robert Egan Associate Editor Cell function is determined by how DNA is expressed into proteins. That process includes two main steps—transcription, when messenger RNA (mRNA) makes copies of active genes; and translation, when mRNA guides protein assembly. Knowing which genes are active at any given moment would make it possible to track the body's response to factors in the...
Woman with advanced Alzheimer's regained speech and memories after taking magic mushrooms
A woman with advanced Alzheimer’s disease saw significant improvements in brain function after taking psilocybin-containing mushrooms. That’s according to a case report recently published in Frontiers in Neuroscience, which focused on an elderly woman who had been living with Alzheimer's disease for about 10 years. The Japanese-American woman, whose name was not shared, had experienced severe functional decline for roughly five years.
Eating ultraprocessed foods tied to a 58% higher risk of developing dementia
Eating ultraprocessed foods tied to a 58% higher risk of developing dementia Eating bacon, ham and other smoked meats was tied to the highest risk to brain health - Bookmark - CommentsGo to comments People who eat over two pounds of ultraprocessed foods like hot dogs and cookies a day are at a 58 percent increased risk of developing dementia and a 46 percent heightened risk for cognitive impairment, an alarming new study from researchers at Harvard’s T.H. Chan School of Public Health shows....
Scientists found the hidden switch fueling alzheimer’s brain inflammation
Scientists found the hidden switch fueling alzheimer’s brain inflammation Scientists may have found a hidden Alzheimer’s “inflammation switch”—and turning it off protected brain connections in early studies. - Date: - May 31, 2026 - Source: - Scripps Research Institute - Summary: - Scientists at Scripps Research have uncovered a molecular “switch” that appears to fuel the damaging brain inflammation seen in Alzheimer’s disease. They found that a protein called STING becomes chemically...